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These include: Nausea Vomiting Diarrhea Constipation Bloating and abdominal discomfort Gastrointestinal Tolerability and Dose Escalation For both tirzepatide and retatrutide, gastrointestinal symptoms are most pronounced during the initial initiation phase and immediately following a dose escalation step

The goal is to understand why inflammatory signaling is elevated and whether modifiable drivers are present: visceral fat, periodontal disease, poor sleep, alcohol, insulin resistance, autoimmune activity, environmental exposure, chronic infection, or unresolved cardiometabolic risk

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Mechanisms of development 121 , 629637, doi:10.1016/j.mod.2004.05.010 (2004)